Direct preparation of copper organometallics bearing an aldehyde function via an iodine-copper exchange.
نویسندگان
چکیده
The iodine-copper exchange reaction allows the direct preparation of various aryl, heteroaryl and alkenyl cuprates bearing a formyl group, thus allowing a direct synthesis of polyfunctional aldehydes without the need of protecting groups or an additional oxidation step.
منابع مشابه
Selective functionalization of imidazoles via an iodine-copper exchange reaction.
The reaction of protected 4,5-diiodoimidazoles with (PhMe2CCH2)2CuLi regioselectively provides 5-cuprated imidazoles, which readily react with various electrophiles furnishing functionalized imidazoles in good yields; remarkably, these resulting mono-iodoimidazoles undergo again an iodine-copper exchange reaction in the presence of sensitive functional groups, like an aldehyde or a ketone.
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ورودعنوان ژورنال:
- Chemical communications
دوره 23 شماره
صفحات -
تاریخ انتشار 2006